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| Registros recuperados : 36 | |
| 2. |  | MOREIRA, G. C. M.; PÉRTILLE, F.; GODOY, T. F.; BRASSOLOTI, R.; BOSCHIERO, C.; LEDUR, M. C.; COUTINHO, L. L. Discovery of candidate genes for fatness in chickens based on genotyping with 600K SNP chip in a QTL region. In: CONGRESSO BRASILEIRO DE GENÉTICA, 60., 2014, Guarujá. Resumos? Ribeirão Preto: Sociedade Brasileira de Genética, 2014. p. 64| Biblioteca(s): Embrapa Suínos e Aves. |
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| 3. | | TREVISOLI, P. A.; MOREIRA, G. C. M.; BOSCHIERO, C.; PETRINI, J.; MOURÃO, G. B.; LEDUR, M. C.; COUTINHO, L. L. Single nucleotide polymorphism associated with breast trait in chickens. In: PLANT AND ANIMAL GENOME CONFERENCE, 26., 2018, San Diego. Abstracts... [S.l. : s.n.], 2018. Paper 29820. Organizers: Sébastien Praud and Kellye Eversole. PAG XXVI.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 4. | | MOREIRA, G. C. M.; GODOY, T. F.; BOSCHIERO, C.; LEDUR, M. C.; GASPARIN, G.; ANDRADE, S. C. da S.; PADUAN, M.; COUTINHO, L. L. Identification of mutations in a QTL region on chromosome 3 associated with fatness in chickens. In: INTERNATIONAL SYMPOSIUM ON ANIMAL FUNCTIONAL GENOMICS, 5., 2013, Guarujá. Programme and abstract book... [S.l.: s.n.], 2013. p. 38. ISAFG 2013. AB.31| Biblioteca(s): Embrapa Suínos e Aves. |
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| 5. | | GODOY, T. F.; MOREIRA, G. C. M.; BOSCHIERO, C.; LEDUR, M. C.; GASPARIN, G.; ANDRADE, S. C. da S.; PADUAN, M.; COUTINHO, L. L. Identification of polymorphisms in a QTL region on chicken chromosome 2 associated with muscle deposition. In: INTERNATIONAL SYMPOSIUM ON ANIMAL FUNCTIONAL GENOMICS, 5., 2013, Guarujá. Programme and abstract book... [S.l.: s.n.], 2013. p. 39. ISAFG 2013.AB.32| Biblioteca(s): Embrapa Suínos e Aves. |
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| 6. | | GODOY, T. F.; MOREIRA, G. C. M.; SILVA, V. H.; BOSCHIERO, C.; LEDUR, M. C.; MOURA, A. S. A. M. T.; COUTINHO, L. L. Identification of CNVs on the genome of Brazilian chicken lines. In: PLANT & ANIMAL GENOME CONFERENCE, 24., 2016, San Diego, CA. [Abstracts...]. San Diego: [s.n.], 2016. Pôster P0646.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 7. | | MOREIRA, G. C. M.; CESAR, A. S. M.; GODOY, T. F.; BOSCHIERO, C.; LEDUR, M. C.; GARRICK, D. J.; MOURA, A. S. A. M. T.; COUTINHO, L. L. Genome-wide association studies reveal genomic windows and candidate genes related to fat deposition in chickens. In: PLANT & ANIMAL GENOME CONFERENCE, 24., 2016, San Diego, CA. [Abstracts...]. San Diego: [s.n.], 2016. Pôster P0647.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 8. | | GODOY, T. F.; SILVA, V. H. da; MOREIRA, G. C. M.; BOSCHIERO, C.; LEDUR, M. C.; CROOIJAMANS, R. P.; GROENEN, M. A. M.; COUTINHO, L. L. Inherited CNVs in regions related to breast muscle development in a broiler population. In: PLANT AND ANIMAL GENOME CONFERENCE, 26., 2018, San Diego. Abstracts... [S.l. : s.n.], 2018. Paper 29816. Organizers: Sébastien Praud and Kellye Eversole. PAG XXVI.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 9. | | KAPPELER, B. I. G.; REGITANO, L. C. de A.; POLETI, M. D.; CESAR, A. S. M.; MOREIRA, G. C. M.; GASPARIN, G.; COUTINHO, L. L. MiRNAs differentially expressed in skeletal muscle of animals with divergent estimated breeding values for beef tenderness. Molecular Biology, v. 20, n. 1, p. 2-11, 2019.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 10. | | ALMEIDA, O. A. C.; MOREIRA, G. C. M.; REZENDE, F. M.; BOSCHIERO, C.; PEIXOTO, J. de O.; IBELLI, A. M. G.; LEDUR, M. C.; NOVAIS, F. J. de; COUTINHO, L. L. Identification of selection signatures involved in performance traits in a paternal broiler line. BMC Genomics, v. 20, n. 449, 2019.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 11. | | MARCHESI, J. A. P.; ONO, R. K.; CANTAO, M. E.; IBELLI, A. M. G.; PEIXOTO, J. de O.; MOREIRA, G. C. M.; GODOY, T. F.; COUTINHO, L. L.; MUNARI, D. P.; LEDUR, M. C. Exploring the genetic architecture of feed efficiency traits in chickens. Scientific Reports, v. 11, n. 4622, 2021.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 12. | | MOREIRA, G. C. M.; SALVIAN, M.; BOSCHIERO, C.; CESAR, A. S. M.; REECY, J. M.; GODOY, T. F.; LEDUR, M. C.; GARRICK, D.; MOURÃO, G. B.; COUTINHO, L. L. Genome-wide association scan for QTL and their positional candidate genes associated with internal organ traits in chickens. BMC Genomics, v. 20, n. 669, 2019.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 13. | | ONO, R. K.; IBELLI, A. M. G.; CANTAO, M. E.; PEIXOTO, J. de O.; SOLLERO, B. P.; SUREK, D.; MOREIRA, G. C. M.; GODOY, T. F.; COUTINHO, L. L.; LEDUR, M. C. Genome-wide association study for femur-related traits in broilers. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 11., 2018, Auckland, New Zealand. Proceedings... Massey University, 2018. Digital Archive.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 14. | | PERTILLE, F.; MOREIRA, G. C. M. M.; ZANELLA, R.; NUNES, J. de R. da S.; BOSCHIERO, C.; ROVADOSCKI, G. A.; MOURÃO, G. B.; LEDUR, M. C.; COUTINHO, L. L. Genome-wide association study for performance traits in chickens using genotype by sequencing approach. Scientific Reports, v. 7, n. 41748, 2017.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 15. | | MOREIRA, G. C. M.; BOSCHIERO, C.; CESAR, A. S. M.; REECY, J. M.; GODOY, T. F.; TREVISOLI, P. A.; CANTAO, M. E.; LEDUR, M. C.; IBELLI, A. M. G.; MOURA, A. S. M. T.; GARRICK, D.; COUTINHO, L. L. A genome-wide association study reveals novel genomic regions and positional candidate genes for fat deposition in broiler chickens. BMC Genomics, v. 19, n. 374, 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 16. | | BOSCHIERO, C.; MOREIRA, G. C. M.; GHEYAS, A.; GODOY, T. F.; GASPARIN, G.; MARIANI, P. D. S. C.; PADUAN, M.; CESAR, A. S. M.; LEDUR, M. C.; COUTINHO, L. L. Genome-wide characterization of genetic variants and putative regions under selection in meat and egg-type chicken lines. BMC Genomics, v. 19, n. 83, 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 17. | | FERNANDES, A. C.; SILVA, V. H. da; GOES, C. P.; MOREIRA, G. C. M.; GODOY, T. F.; IBELLI, A. M. G.; PEIXOTO, J. de O.; CANTAO, M. E.; LEDUR, M. C.; REZENDE, F. M. de; COUTINHO, L. L. Genome-wide detection of CNVs and their association with performance traits in broilers. BMC Genomics, v. 22, n. 354, 2021.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 18. | | GONÇALVES, T. M.; REGITANO, L. C. de A.; KOLTES, J. E.; CESAR, A. S. M.; ANDRADE, S. C. da S.; MOURAO, G. B.; GASPARIN, G.; MOREIRA, G. C. M.; FRITZ-WATERS, E.; REECY, J. M.; COUTINHO, L. L. Gene co-expression analysis indicates potential pathways and regulators of beef tenderness in Nellore cattle. Frontiers in Genetics, v.9, n. 441, p. 1-18, 2018.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 19. | | MOREIRA, G. C. M.; BOSCHIERO, C.; CESAR, A. S. M.; REECY, J. M.; GODOY, T. F.; PÉRTILLE, F.; LEDUR, M. C.; MOURA, A. S. A. M. T. M.; GARRICK, D. J.; COUTINHO, L. L. Integration of genome wide association studies and whole genome sequencing provides novel insights into fat deposition in chicken. Scientific Reports, v. 8, n. 16222, 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 20. | | MOREIRA, G. C. M.; GODOY, T. F.; BOSCHIERO, C.; CESAR, A. S. M.; REECY, J. M.; LEDUR, M. C.; GARRICK, D.; SILVA, V. H. da; CROOIJAMANS, R. P.; GROENEN, M. A. M.; COUTINHO, L. L. Integration of GWAS, CNV and sele ction signature reveals candidate genes for abdominal fat regulation in chickens. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 11., 2018, Auckland, New Zealand. Proceedings... Massey University, 2018. Digital Archive.| Biblioteca(s): Embrapa Suínos e Aves. |
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| Registros recuperados : 36 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
19/02/2019 |
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Data da última atualização: |
19/02/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
GONÇALVES, T. M.; REGITANO, L. C. de A.; KOLTES, J. E.; CESAR, A. S. M.; ANDRADE, S. C. da S.; MOURAO, G. B.; GASPARIN, G.; MOREIRA, G. C. M.; FRITZ-WATERS, E.; REECY, J. M.; COUTINHO, L. L. |
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Afiliação: |
Tássia Mangetti Gonçalves, USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; James E. Koltes, Iowa State University; Aline Silva Mello Cesar, USP; Sónia Cristina da Silva Andrade, USP; Gerson Barreto Mourão, USP; Gustavo Gasparin, USP; Gabriel Costa Monteiro Moreira, USP; Elyn Fritz-Waters, Iowa State University; James M. Reecy, Iowa State University; Luiz Lehmann Coutinho, USP. |
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Título: |
Gene co-expression analysis indicates potential pathways and regulators of beef tenderness in Nellore cattle. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Frontiers in Genetics, v.9, n. 441, p. 1-18, 2018. |
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Idioma: |
Inglês |
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Conteúdo: |
Beef tenderness, a complex trait affected by many factors, is economically important to beef quality, industry, and consumer?s palatability. In this study, RNA-Seq was used in network analysis to better understand the biological processes that lead to differences in beef tenderness. Skeletal muscle transcriptional profiles from 24 Nellore steers, selected by extreme estimated breeding values (EBVs) for shear force after 14 days of aging, were analyzed and 22 differentially expressed transcripts were identified. Among these were genes encoding ribosomal proteins, glutathione transporter ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (ABCC4), and synaptotagmin IV (SYT4). Complementary co-expression analyses using Partial Correlation with Information Theory (PCIT), Phenotypic Impact Factor (PIF) and the Regulatory Impact Factor (RIF) methods identified candidate regulators and related pathways. The PCIT analysis identified ubiquitin specific peptidase 2 (USP2), growth factor receptor-bound protein 10 (GBR10), anoctamin 1 (ANO1), and transmembrane BAX inhibitor motif containing 4 (TMBIM4) as the most differentially hubbed (DH) transcripts. The transcripts that had a significant correlation with USP2, GBR10, ANO1, and TMBIM4 enriched for proteasome KEGG pathway. RIF analysis identified microRNAs as candidate regulators of variation in tenderness, including bta-mir-133a-2 and bta-mir-22. Both microRNAs have target genes present in the calcium signaling pathway and apoptosis. PIF analysis identified myoglobin (MB), enolase 3 (ENO3), and carbonic anhydrase 3 (CA3) as potentially having fundamental roles in tenderness. Pathways identified in our study impacted in beef tenderness included: calcium signaling, apoptosis, and proteolysis. These findings underscore some of the complex molecular mechanisms that control beef tenderness in Nellore cattle. MenosBeef tenderness, a complex trait affected by many factors, is economically important to beef quality, industry, and consumer?s palatability. In this study, RNA-Seq was used in network analysis to better understand the biological processes that lead to differences in beef tenderness. Skeletal muscle transcriptional profiles from 24 Nellore steers, selected by extreme estimated breeding values (EBVs) for shear force after 14 days of aging, were analyzed and 22 differentially expressed transcripts were identified. Among these were genes encoding ribosomal proteins, glutathione transporter ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (ABCC4), and synaptotagmin IV (SYT4). Complementary co-expression analyses using Partial Correlation with Information Theory (PCIT), Phenotypic Impact Factor (PIF) and the Regulatory Impact Factor (RIF) methods identified candidate regulators and related pathways. The PCIT analysis identified ubiquitin specific peptidase 2 (USP2), growth factor receptor-bound protein 10 (GBR10), anoctamin 1 (ANO1), and transmembrane BAX inhibitor motif containing 4 (TMBIM4) as the most differentially hubbed (DH) transcripts. The transcripts that had a significant correlation with USP2, GBR10, ANO1, and TMBIM4 enriched for proteasome KEGG pathway. RIF analysis identified microRNAs as candidate regulators of variation in tenderness, including bta-mir-133a-2 and bta-mir-22. Both microRNAs have target genes present in the calcium signaling pathway and apoptos... Mostrar Tudo |
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Palavras-Chave: |
Maciez da carne; Qualidade da carne. |
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Thesagro: |
Carne; Gado de Corte. |
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Thesaurus NAL: |
Beef; Beef cattle; Beef quality. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/193047/1/8-GeneCo-expressionAnalysis.pdf
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Marc: |
LEADER 02810naa a2200325 a 4500
001 2106256
005 2019-02-19
008 2018 bl uuuu u00u1 u #d
100 1 $aGONÇALVES, T. M.
245 $aGene co-expression analysis indicates potential pathways and regulators of beef tenderness in Nellore cattle.$h[electronic resource]
260 $c2018
520 $aBeef tenderness, a complex trait affected by many factors, is economically important to beef quality, industry, and consumer?s palatability. In this study, RNA-Seq was used in network analysis to better understand the biological processes that lead to differences in beef tenderness. Skeletal muscle transcriptional profiles from 24 Nellore steers, selected by extreme estimated breeding values (EBVs) for shear force after 14 days of aging, were analyzed and 22 differentially expressed transcripts were identified. Among these were genes encoding ribosomal proteins, glutathione transporter ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (ABCC4), and synaptotagmin IV (SYT4). Complementary co-expression analyses using Partial Correlation with Information Theory (PCIT), Phenotypic Impact Factor (PIF) and the Regulatory Impact Factor (RIF) methods identified candidate regulators and related pathways. The PCIT analysis identified ubiquitin specific peptidase 2 (USP2), growth factor receptor-bound protein 10 (GBR10), anoctamin 1 (ANO1), and transmembrane BAX inhibitor motif containing 4 (TMBIM4) as the most differentially hubbed (DH) transcripts. The transcripts that had a significant correlation with USP2, GBR10, ANO1, and TMBIM4 enriched for proteasome KEGG pathway. RIF analysis identified microRNAs as candidate regulators of variation in tenderness, including bta-mir-133a-2 and bta-mir-22. Both microRNAs have target genes present in the calcium signaling pathway and apoptosis. PIF analysis identified myoglobin (MB), enolase 3 (ENO3), and carbonic anhydrase 3 (CA3) as potentially having fundamental roles in tenderness. Pathways identified in our study impacted in beef tenderness included: calcium signaling, apoptosis, and proteolysis. These findings underscore some of the complex molecular mechanisms that control beef tenderness in Nellore cattle.
650 $aBeef
650 $aBeef cattle
650 $aBeef quality
650 $aCarne
650 $aGado de Corte
653 $aMaciez da carne
653 $aQualidade da carne
700 1 $aREGITANO, L. C. de A.
700 1 $aKOLTES, J. E.
700 1 $aCESAR, A. S. M.
700 1 $aANDRADE, S. C. da S.
700 1 $aMOURAO, G. B.
700 1 $aGASPARIN, G.
700 1 $aMOREIRA, G. C. M.
700 1 $aFRITZ-WATERS, E.
700 1 $aREECY, J. M.
700 1 $aCOUTINHO, L. L.
773 $tFrontiers in Genetics$gv.9, n. 441, p. 1-18, 2018.
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Embrapa Pecuária Sudeste (CPPSE) |
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